X-COM: UFO Defense CONFIRMED WORKING on Vista 64-bit
It's hard to find the game itself these days, but playing the game through DOSBox can be a bit of a hassle. I prefer to play with the Gold Edition release for Windows.
Thus, I tried for two hours to get the game working. I tried both f0dder's patch and XCOMUTIL96 before I came across Mok's patch, which worked. I can't find the link anymore, but I just wanted to spread the good news to Vista users; this board is the first one you find on Google.