The obvious answer to me is Mass Effect. I've never played the Baldur's Gate games on PC, but Baldur's Gate 2: Dark Alliance on the XBox didn't seem anything like KotOR at all - I only played about an hour of it though.
Mass Effect is pretty standard fare, storywise, for Bioware. The combat engine is wildly different - it's something of a 3rd person shooter merged with an RPG. If that turns you off, then you'll probably want to pass on it.
I've never played the Baldur's Gate games on PC, but Baldur's Gate 2: Dark Alliance on the XBox didn't seem anything like KotOR at all
The PC Baldur's Gate games are extremely similar, gameplay wise, to the KOTORs; dice-rolling, under-the-hood, quasi-real-time combat engine. The BG: Dark Alliance games for Xbox and PS2 are more akin to the X-Men legends or Marvel Ultimate Alliance games - straight up action RPGs. I prefer the former over the latter, but both are good offerings for their particular genres.
I feel the end is near, my little Monday night whore. My little Saturday night, became a Sunday remorse.
If you like Star Wars, I'd recommend Star Wars: The Force Unleashed. It's pretty much a straight up Action game with a few RPG elements. It's got a pretty good story (it tells the tale of how the rebel alliance was formed, something that was missing from the movies) and very good voice acting. Not to mention that the Force Powers are extremely fun to use. It's definately worth a rental.
All that is gone, and All that's to come,And everything under the sun is in tune, But the sun is eclipsed by the moon-Eclipse, Pink Floyd