Most favorite: Hard to tell, I like quests as the physcian or blacksmith because I like playing as them between quest tasks but I like Jacobian priest quests because they're pretty funny in the "HEATHENS! Heathens everywhere!" sort of way
Least favorite is the Fishing Competition if you chose to take advice from the non-crazy fisherman. (the one that isn't the jester hat in the quest choice) If you go with him you have to fish with low focus to catch the pity lobster. I normally have full focus all the time because I'm super efficent so that is a big pain. With the crazy guy you just have to buy a whaling boat and harpoon and go whale hunting at the end of his quest.
I should not walk so a child may live.----http://www.spore.com/view/profile/Catsimboy
I think my favourite so far is the Meat Quest IV. It's a little obsessive over meat, but you can end up going down some very strange decision trees....My less than savoury merchant ended up addicting the entire kingdom to 'dubious meat of mystery origin'....I just hope they don't all start having nosebleeds later =)
Where's the Kaboom? There was supposed to be an Earth-shattering Kaboom!