The hardest one they give me at first. The point of these games are that they have to kick your ass to make you play better. Unless I reach a difficulty that's too high, I'm using the top one. --- PSN: MarkoKri
I've been getting into the habit of starting a game on the hardest difficulty if there are trophies for each difficulty.
I've done it on Bioshock 2, Deus Ex: Human Revoltion and RE6.
If DMD is available from the start (and the trophies stack), I will start on DMD. --- There is no such thing as a "Quick Time Event done right". A game that has Quick Time Events is a "video game done wrong".