Its world seems to have much more potential, with further growth for its lead characters.
DMC5, on the other hand, just has Nero. Dante already peaked. You could bring Vergil back, sure, or Mundus--but what would either really accomplish? We've been there and done that, and neither has any real significance to Nero, who, by all accounts, would have to become the series' next protagonist.
Yea, Dante is already god mode, they will go into Dragonball GT levels of stupid if they insist on him being the MC. Have him off starting a family or something, expand on Nero his existence needs explained. (Kinda doubt Vergil knocked up a prostitute at eleven.) Give him some new equipment.(That was the main problem with him, lack of variety.)
Official Pyro Jack of the SMT IV board. http://www.youtube.com/watch?v=ibyOMDcyO3U