I don't think that RE needs a reboot. More of major changes to gameplay, themes and plot. The characters, storyline, settings and theme of the game are quite good. Reboot means losing the "soul" of the series.
Seeing where the game is at now, definitely Resident Evil. And the changes wouldn't even be that jarring as with DmC, since RE is pretty western to begin with. The biggest change would probably be that Leon gets a haircut.