Claire. It would add an immense amount of tension in the series, especially for Chris. That can really change the way he acts. It might also have an affect on Leon and Sherry(if she somehow is in contact with her/will be in contact).
Other than that, I'd rather Chris, Jill and Leon not die. However:
Bring back Barry (lol bbb) and have him sacrifice his life for Chris. It would fit because they are close to each other.
Bring back Rebecca and kill her off. Kill Carlos off in a flashback.
ElusionM: Resident Evil classics never gave me any input delay squiggy9996999: you act like you never opened a door, jumped down a ledge or climbed a ladder
I hope Jake doesn't die. It's bad enough his papa died. I would have to say Leon / Ada. Don't care for either but I think if either one died, it would greatly impact the other one regardless of their current situation with eachother.