It's a great challenge. Being grabbed by a single leaping zombie will take off 5 bars of your health, a basic melee attack deals about 3 bars of damage from any enemy and practically every boss attack will put you in instant dying status. Couple that with no skills, incredibly aggressive enemies, greatly limited ammo (the game is programmed to drop skill points at a much higher ratio on No Hope, thus ensuring that you are limited on ammo), bullet sponge enemies and bosses, and no full restore upon death, and you have yourself one awesome (and sometimes frustrating) experience ahead of you. RE 5's Pro Mode is still the toughest of the Resident Evil series Campaign difficulties (along with RE 0's hard mode, Remake's Hard mode, and RE 2's Nightmare mode) No Hope is still a great challenge.
When facing a zombie apocalypse, don't join up with a group. Why? Because you'll end up blowing your own head off due to all the pointless drama caused within.