Just because someone survived a terrible situation doesn't mean they have to dedicate their entire life to it. Claire only reappeared (once) because she was Chris' (who is arguably the series' main character) sister, and she more than likely received some sort of training from him in the past. There's no reason the Outbreak cast wouldn't go back to living normal lives.
Plus, I personally never consider anything outside of the main series cannon anyway, safe for the side stories in UC and DC.
Waluigi is the coolest Mario character, and Resident Evil 6 was fantastic; Everyone's entitled to their own opinions.