Personally, if what I hear of this going back to survival horror stuff is true, then Claire is the only logical candidate.
Good o' Claire, in her non-military capacity, finds herself in the middle of a s***storm. Sherry goes rescue her in a reversal of roles. Meanwhile, reinforcements arrive in the form of Jake and Jill, who went up the hill, and had some awkward moments recounting Wesker before indulging in some Jill Sandwich.
4 is enough, tbh.... good for 2 campaigns, if we must continue this pattern. RE 6 had too many storylines, I think, and little length/depth to each story.