To the person who mentioned about Leon doing the laser thing
I guess you have never played Resident Evil Umbrella Chronicles
The canon scenario where Chris and Jill are actually the ones to take down Umbrella. NOT Leon. This was in 2003, before Resident Evil 4. And there was a laser room that Jill and Chris both went through and managed to still come out alive with acrobatic moves.
My opinion, is that Chris would win with a landslide due to what everyone has already stated. Way more training and more muscular. However more muscles does not mean less agility.