honestly in your first run through the game, don't take things too seriously like min/maxing your stats or getting the "best" weapon, take this time to explore and just enjoy yourself.
This. Nearly every topic on builds is dealing with experienced players, and generally a pvp slant. Play your first run through with a focus on just finishing it --- http://www.last.fm/user/DrDissonance grimgastronomicon.wordpress.com
Read nothing. No guides, no forums, no wikis...NOTHING. Enjoy the game. If you don't like it, no big deal. If you do like it, you're probably going to play through it many, many times. But you'll never be able to play through it the first time again, and every little thing you read without being able to experience it yourself first will hurt your experience.
Second playthrough? Go hog wild. Read up as much as you want on the game.