I read up a little on Seven Pillars of Wisdom by T.E. Lawrence (Lawrence of Arabia), Iram of the Pillars and the Empty Quarter, but I cannot find any information on ancient artifacts.
Any ideas or speculation on what the main treasure will be? Any clues from the screen shots or trailer? The trailer showed T.E. Lawrence's autobiography, so I believe this game will have something to do with that.
I believe that in Uncharted 3: Drake's Deception that Drake will seek after an artifact that Lawrence of Arabia was involved with. I'm just guessing. Whether or not T.E. Lawrences autobiography describes anything like that, I do not know. However, the games are loosely based on facts, and are more fiction, so they could create a fictional story within U3 about T.E. Lawrence and some mythological treasure.
The hand of Midas would be incredibly awesome! However, does it have a link to Iram of the Pillars, Empty Quarter, or Lawrence of Arabia? The artifact would need to tie in somewhere, and I don't know much about the tale of King Midas.
Drake could turn the entire world into gold, just like that Duck Tales episode!