Even without Elena, Drake would be unworthy. His finds are so insignificant compared to Lara's. Sure he found a lost city or 2, and the proverbial "fountain of youth", but that doesn't compare to Atlantis, Excalibur, Mjolnir, The Dagger of Xian, and Yamatai.
As for TCs question, there's few human video game characters as Iconic as Lara, she's up there with Mario and Pikachu. I don't think there's any VG character worthy of her.
So...You're saying Mario or Pikachu have a fair chance? Peach and Ash are gonna be jelly.
Soul of the Mind key to life's ether, Soul of the lost withdrawn from it's vessel, Let strength be granted so the world might be mended- Maiden in Black