I think you need to set it each time you load a file.
Don't play around with timescale though. It bugs your save to hell eventually, and the bugs get more pronounced and gamebreaking as the game goes on. They won't be obvious at first. If you've been doing this for a while on your save, you've more than broken it.
that sucks.. i've wanted to set the time to real time for awhile. i find time goes way too fast in these games. if it's night and i want day, then i'll sleep till then. but i hate when it's the day and it's good to go out wandering, then it's night in no time flat. or you get to a town and it's 5pm and you have to rush to hit up all the stores before they close.
Switch2Nine6 posted... I wouldn't do this, bugs the hell out of MANY quests/other things in Skyrim I am told.
Are you sure on this. Mine has been set to 12(5 real time minutes = 1 gametime hour)
I haven't ran across any glitches or bugs. Well except for the one the last patch gave me with the Dragons flying backwards and unkillable. Which is why I'm waiting patiently for the new patch to fix this and start playing again.
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Changing timescale should have no negative effects. It hasn't in past games. It's a global variable, so its value is baked into saved data. Unless something (or you) changes it, it should stay at whatever value you set. I personally play at timescale 5. I've played a couple hundred hours on several characters and never seen an issue with it. All the time spent in Oblivion, Fallout 3, and New Vegas with a modified timescale adds up to a few thousand hours and, again, there is no issue that it caused that I'm aware of.
kwong0028 posted... Does timescale affect potion duration?
Of course not. The duration of effects and spells is always measured in real time.