As far as i know this bug mostly only affects multi monitor setups.
This solution will completely fix the problem. You may have to tweak the command line to exclude more cursor types if you run apps that change the cursor type at the same time as you have skyrim running.
Warning this program will completely hide your mouse. If you are not familiar with short cuts like
ctrl + r = run, then type cmd.exe
alt + tab = switch between open applications
then you may think twice about using this app
Download this archive (im using version 1.5 beta on nvidia gtx580 Win764-bit)