If it's a new IP, I want a Metroid-vania style beat-em up with some sort of relationship mechanic, with the ability to have multiple party members. Party members can help out either through assists (Like in UvC2 and Skullgirls) or switch characters directly (Castlevania: Portrait of Ruin).
If not, I want an ENHANCED port of Dark Cloud 2. Yes, it'd be awesome to have it finally on HD, but new weapons, tweaked AI, new locations, improved monster transformation system, and more stuff for Georama, would be welcomed. Also, more Monica animations! Hmmmmmm.