I've played through this game twice now (probably my favorite game of all time). Both 100 percent completion. My first one was on medium with no limitations. The second one was on the hardest with no fast travel and only using actual stores to buy/sell guns and loot.
I'm thinking of doing a third run of the game with a No Death limitation, allowing fast travel and vending machine usage but once I die I'm done.
What are some other good ideas for an interesting and fun way to play? --- Youtube Channel : http://www.youtube.com/user/EndorphinRush23?feature=mhee
Suggestions: * Limit weapon usage... with the exception of hunting with specific weapons and when you're required to use certain weapons. eg only pistols and takedowns, no silenced weapons, bow and knife only etc. * No crafted syringes... so you can still buy medicine and pick it up but no crafting syringes (you could sell the plants or just not pick them up).