My current build is Pryomancy, Leylines, Bloodmage, Perception, Tinker, Weapon of choice and Dodge. First three to nuke anything in the path, perception + tinker for far trap vision and trap dismantling (no more deaths by traps), whatever weapon to use until level 2 then drop fire traps to kills mobs and dodge just for the jump, this can be opted for your preference since nothing will get close to you.
Currently in the middle of floor 5 with this build
I've had pretty good luck with Unarmed, Vampirism, Assassination, Burglary, Astrology as the core of my build and then add in two other filler skills (usually alchemy/fungal and some other magic skill)
You'll be stunning almost every round, doing crazy counter damage and have tons of survivability.