Best line-up? I'm not gonna run anchor Vergil, I'm run Dante.
I'm more than capable with each of the characters, so only advice I need it best DHCs, assists, and maybe best Round Harvest setups? --- Normally I would concede, but Tobi lies about everything. He even lied to himself in his own monologue. - GuideToTheDark
I personally like trish/dante/vergil because trish -> dante and dante -> vergil are good DHC'S that can really eliminate the mediocre damage trish/dante have and you can clutch out Totally Deserved and Skillful wins with dark vergil
Given that poll at least 1 person likes every single configuration so just throw things out and see what you like.