You're trolling for sure. Tell me that again when you read/watch stuff like Ghost in the Shell, Akira and others of the like. Anyway no Borderlands as an anime would not work. However as a series I think it could work. CG or standard animation with the same wit and sense of humor in the writing would be fine.
I could definitely see it as an animation, when taking the word anime's true meaning into consideration.
Not as the popular notion of somewhat cutsey, cleanly animated sort of stuff that's often associated with anime of course, but I mean the whole thing is practically a cartoon already, all the characters being exaggerated etc so it wouldn't be much of a stretch.