I personally focused on the right skill tree with my Siren. MAKE SURE you get that last skill in that tree. I think it's called Ruin. I destroy people so easily when Ruin is active. --- I have Dysarthria. It's a Speech problem. Your question is answered now.
I have both a Maya and Gaige. I have to say when it comes to DMG I choose the Mechro. LBT and OC combo is a force to reckon with. Then again I don't use an offensive siren. She is without a doubt the medic when I play Co-op. Lolz. Harmony Tree all the way down to Scorn. --- GT: Steve0314