Rampage Brawn. The regen while zerked is essential to avoid spending your life on your knees... uh... that sounded bad... but really. if you get taunt with it at level 57 or whenever there're enough points, you're practically a god because you have so much health, s much damage resist, so much regeneration, and the ability to once-per-zerk full heal and get even more tanky for 10 seconds. i highly recommend vitality relic and neogenater because the neo's health addition is effected by the "Hard to Kill" and vitality relic's percent boost. i am only 53 and i have 179k HP. with a black vitality relic, i hit 309k HP. that in tandem with more than 6% regen while gunzerking and you pretty much can't die, even with the fair purple relic. [except blowing yourself up with a nukem, norfleet, or tunguska in sanctuary (which i have done many times)]
I use Rampage/Brawn with a titan mod. The combination of being an unstoppable tank with a 38%+ damage boost on top of that pretty much makes me steamroll everything. Throw in an adaptive shield for some serious lolz.
Gamer for life, 31 years and counting. A life without video games is not a life worth living.