It works against Hyperius, but not Gee. Hyperius and his minions can have shields surrounding them, which reduce the damage they take to 10% of what it would normally be, and I think the shields can also reflect bullets back at you(not 100% positive about that, but I think it happens sometimes). The Bee definitely still works against them though, but use it at your own risk since it's pretty easy to die without high shields and health. As for Gee, I think he's just immune to all damage dealt by your guns/grenades/etc while his shield is up, and I haven't even seen his shield go down at all while the acid from the worms eats up his health. So the Bee is useless against Gee(hey, that rhymed!).