It's all in your play style dude. 4-4-2 is pretty standard and you can use it with just about any team.
Some teams have personell that requires different formations. The 4-3-3 for instance allows more wing play so if you have good wings it might be a better option. It all depends.
I go with the 4-3-1-2 or whatever it is where I have two strikers and a center forward usually, but again, you gotta have the personnel to make that work. In my club career team, I always have an excess of strikers and I like having lots of options on offense. In video game football, It critical especially late in close games to have a lot of focusa on offense.
In UT, I personally never go below 4 defenders. Other players are too good and they'll counter you too fast if you get cute and try to be too aggressive.
4-5-1, 4-4-1-1 and 3-4-1-2 are the best if you know how to pass and dribble since you'll dominate possession and create great scoring chances. If you're bad play 4-3-3 or 4-4-2 and just run the wings and spam crosses in or play 4-1-2-1-2 (obviously on assisted) and do nothing but pingpong pass then spam LB+Y.
Let's be honest, the cards on the table, Jealousy's a sin, Cain killed Abel, Backstabber, Caesar had Brutus, It's hard to weed 'em out, even Jesus had Judas