They're obviously going to want our money, so I doubt that it will be two obscure characters. The names should at least be recognizable.
All of the talk about Abe leads me to believe one will be him, but... the other? That's a tough call. Crash or Spyro if Ubisoft (?) feels like forking them over. Square-Enix would probably be willing to throw Lara Croft, or god forbid, a noteworthy Final Fantasy character like Cloud Strife at the game.
Realistically, the second character will probably be a little less known than any of those choices, but Abe is probably a good pick. There's simply been too much news (including negative) about him lately.