Well, I play as everyone, but I'd say Drake and Sly are my favorite characters. I think Drake is one of my best, and I like playing as Sly a lot too. --- Robbit (Jumping Flash!) for Playstation All-Stars!
I don't really have a main, but I just use the characters because they're funny in some way.
Heihachi - Dat manthong + Manly laugh Zeus - Godly laugh Toro - Catly chuckle Parappa - Tonight: you Radec - U lak skill. Well I also used him since the beta and he's still fun Evil Cole - FEEEEEL that power, baby Drake - Wow, you look like hell. Plus spamming his tranquilizer thingy is a fun way to annoy people --- ( ^_^)/\(^_^ ) Maya high five!
Jak is my favorite person in the game but I originally couldn't really work with him, so i started maining Sly, but that felt too easy and the game stopped being fun. So I finally learned Jak and loved him. Starting subbing Emmett for awhile but he's too frustrating in 2v2.
I've been maining Isaac since I was afraid to try post-patch Jak. I'm just relearning him now and starting to kind of main him again.