Isaac only if he is able to zone effectively. He has several weapons that can dismember Hulk. If Hulk some how dodged and evaded all of Isaac attacks then 1 blow MAY finish Isaac.
Draw me a giant poster depicting this epic battle plz.
I don't have the tools for that.... and I only use what tools I have for Jak related things only :)
....However I can ensure you the battle would be very short, but still interesting to watch. Unlike Isaac, Iron Man, which is basically a super powered Isaac without guns should not be compared to Isaac when it comes down to who is better or who would win in a fight, can take a couple hits and have a better chance of winning.
Oh, but Isaac would have an ensured win if the battle was somehow taken to space. Space is home field advantage for Isaac when it comes down to battles like these.
"It's heading for the city. We gotta defend it... for Damas."