I can keep playing through that urge to kill people and usually do. To when it hits? Depends really. Some days I can go forever without it hitting it. Others it'll start as soon as the first game hits.
That said, it's usually more dependent on my personal mood before I start rather than the game itself. .
GamerTag: Te1vanni Guard "Telvanni you would disprove everyone. :D"- Saint_of_Misery