I'm already predicting that Superman is going to win all the ones on the other side of the brackets, so it may end up being Bats vs Supes. I don't want to jinx anything though.
I really wanted to see Harley vs Joker, but hey, that's why you spend the money to play these out yourself. With 'Marvel Nemesis' on Playstation 2, Venom versus Spiderman turned out to be as epic as I thought it would.
"Game..Over..Hehheheh.." --Venom, Marvel Nemesis: Rise of the Imperfects