Really depends. I was lucky enough to get two of Table 6's best charms, and I have 4 different set ups using these two charms:
Hearing+4 Bomb Boost+10
Guard+4 Expert +10
along with a basic hearing +5 charm
With it, the four sets I alternate with depending on the situation are:
Critical Eye+3 Sharp+1 Razor Sharp HP+50 --------- Critical Eye +2 Bombardier Sharp+1 Razor Sharp HP+50 (with one slot Dios weapons like Gunlance/hammer) ---------- Earplugs Bombardier Sharp+1 Razor Sharp HP+50 ----------- HGE Sharp+1 Razor Sharp HP+50 (With any slotted weapon, doesnt require a slot with a +6 hearing charm or better).
Earplugs is always great, and Expert is just more damage, which is nice. My suggestion though is to review all your charms, and pick one that you can benefit the most from, then work from there. With 8 slots the sky is the limit.
EDIT: You use hammer like me, and dual swords, both which drain stamina for attacks. It's imperative that you gem away Short Sprinter. Only takes one slot, of course.
"We're whalers on the moon!" "We carry a harpoon!" "But there ain't no whales so we tell tall tales and sing a whaling tune!"
My Yamato Prime has Health +20, Sharpness +1, Razor Sharp, and Evasion +2, works quite well for DS/SNS/LS/SAX.
I have it gemmed and registered for several set combinations as well, like for Lancing it has Guard +2, or if I'm fighting Jhen / Miralis or any enemy that Evasion doesn't work well against, I've got Attack Up Large.