I have a US machine and live abroad. My console's region is set to the US. So when I get live and play Titanfall will I be playing against people in the US, people in the nearest region to me, or is it a global thing? Does multiplayer change from game to game?
Suffer what there is to suffer, enjoy what there is to enjoy. Regard both suffering and joy as facts of life.
Resident Evil (and other games that have server browsers) let you choose which region because the game doesn't randomly match you with people. If the game just randomly matched you with people, it would do its best at finding the less laggiest servers to you. It's the same way COD or Halo does it.
One of the things with console gaming is having most of the harder to understand stuff taken away from you, like using IP addresses to connect to people or worrying about what server you connect to. It's all just to make things easier to understand.