Credit to UAV_ONLAHN. He wrote this 12 months ago on TTP board
"It is evident that Herman Melville's Moby-Dick may be a large influence to the story's plot. Take for example, the words that start the novel: "Call me Ishmael" - clearly alluded to in the game's trailer. To some, Moby-Dick is 700 pages about whales, while to some it is one of the greatest spiritual and psychological allegories ever written. Let us explore some of the aspects of the novel and how they relate to the game.
Fire. In the trailer and gameplay sequence we see a spirit of fire appearing, knocking Ishmael and Big Boss down with its force. One of the most significant monologues in Moby-Dick relates to fire, spoken by Ahab. Ahab had lost his leg by the whale Moby-Dick (ironically, while the book's titular whale is a sperm whale, the game portrays a right or baleen whale in the trailer,) and the act of losing his leg drives him to monomania - the invincible desire to destroy the white whale by all means, to the point of driving his crew to death and destruction. Does Big Boss drive his army to destruction? Does Big Boss enter a monomanic state in his desire to abolish Cipher or the Patriots?
Nevertheless, let us revert to the theme of fire. In the 119th Chapter of Moby-Dick, this was Ahab's monologue: " “Oh! thou clear spirit of clear fire, whom on these seas I as Persian once did worship, till in the sacramental act so burned by thee, that to this hour I bear the scar; I now know thee, thou clear spirit, and I now know that thy right worship is defiance. To neither love nor reverence wilt thou be kind; and e’en for hate thou canst but kill; and all are killed. No fearless fool now fronts thee. I own thy speechless, placeless power; but to the last gasp of my earthquake life will dispute its unconditional, unintegral mastery in me. In the midst of the personified impersonal, a personality stands here. Though but a point at best; whenceso’er I came; whereso’er I go; yet while I earthly live, the queenly personality lives in me, and feels her royal rights. But war is pain, and hate is woe. Come in thy lowest form of love, and I will kneel and kiss thee; but at thy highest, come as mere supernal power; and though thou launchest navies of full-freighted worlds, there’s that in here that still remains indifferent. Oh, thou clear spirit, of thy fire thou madest me, and like a true child of fire, I breathe it back to thee.” [Sudden, repeated flashes of lightning; the nine flames leap lengthwise to thrice their previous height; Ahab, with the rest, closes his eyes, his right hand pressed hard upon them.]"
Ishmael injects Big Boss with digoxin, a drug which is not hallucinatory. Perhaps it is important to note Big Boss's prosthesis; which grants him the ability to turn on a motorcycle engine, complete with the virtues of flexing and stretching fingers. Ahab's own prosthesis, in Chapter 108 of Moby-Dick, is described as: "What a leg this is! It looks like a real live leg, filed down to nothing but the core; he’ll be standing on this to-morrow; he’ll be taking altitudes on it."
I smell deep parallelism... O Kojima! It was thou that bid welcome to the eve of such storytelling, like a new Melville resorting to the most elusive of revelations."
Kojima confirms in new interview at 11 min https://www.youtube.com/watch?v=WYCSzu-FmPw --- People that approve of this video 10 & counting! http://www.youtube.com/watch?v=YEPtCLAubaw