A game with both Hoenn and Kanto as regions. But Kanto isn't like GSC Kanto. Maybe the Battle Frontier could be spread around the region like in the anime. I know people don't usually like anime influence, but it would give a second region a use. <.<
Then put Sinnoh and Johto together and do something similar. That way instead of 100 remakes we can just have one big gen 3 remake and one big gen 4 remake.