My first Nuzlocke run was on Blue and it ended in the Viridian Forest but it's mostly because I went overkill by adding a no Poké Center healing rule. That rule is pretty stupid because you'll eventually lose by running out of PP. An alternative is to remove the limit on Pokémon you can catch so that you can keep replacing them all the time or you can use a cheat device to give you unlimited PP. I decided to just forget about custom rules and went with the original ones. The game started very hard but eventually became extremely easy, I even defeated the Elite Four without losing a single Pokémon and I never had to grind. I even caught Zapdos, Articuno, Moltres and Mewtwo by using repels. My starter didn't make it though.