An extremist evil team that mirrors dangerously close to a real life thing, where the regular trainers are separated from their Pokemon, which leads to tiny villages forming to fight back at them.
The leader is an Human supremacist who desires to experiment on Pokemon from such things such as dissection and selective breeding so that he could potentially study and activate DNA within his own body to unlock possible latent powers, but in the end suffers from some sort of degeneration that eventually turns him into some sort of twisted bestial Pokemon.*
* There's trainers who has Psychic abilities and a few that can use Aura (not mentioned in games, but in anime/movies), i wonder if the original Sinnoh Myths was alluding to the fact that Humans and Pokemon was compatible, but after isolation amongst their own kind, became a separated species.
The Psychic powers and aura control could be potential recessive or evolution throwbacks to their more primordial days.
RSN: Plucky9, Total: 2356 KoL: Plucky, currently a Avatar of Jarlsberg