Male Favorite: Hilbert, mostly because he looks a bit older than the rest of them. I also like his design. It's basic, but it works somehow. Least favorite: Sadly it doesn't work for Calem, who I think looks dull. I also don't like Ethan, especially not as an NPC, because his redesign completely destroyed that somewhat cocky attitude he had in Gen II. I mean, just compare his artwork: http://bulbapedia.bulbagarden.net/wiki/Ethan_(game) .
Female Favorite: Hilda. Tough choice, this one. The design of the girls has been consistently great and even new addition Serena is no exception to that. In fact, she may be the best designed female protagonist to date. Still, I chose Hilda mostly for the same reason I chose Hilbert. I also like how she's not so typically "girly" like most other girls, except for Kris perhaps. Talking about Kris... Least Favorite: ...Replacing her with Lyra was completely unnecessary. I don't hate Lyra, but it does make her my least favorite female protagonist.