Given the microphone functions on the 3DS, I'd love to see a comeback of "Hey You, Pikachu!" Just make it like a Pokemon equivalent of Nintendogs, minus the required commitment of playing every day or your pet will hate you BS.
4e is not D&D, but WoW making a Disguise check. Pokemon Black Friend Code: 0605-2800-9952; Trainer Name: Solace; First Pokemon (roleplaying): Snivy (Monty)
Start off in Kanto and progress like the normal Yellow version, then after the elite four your team gets stole by Team Rocket and you have to search for them in Johto. For example, one would be held at Slowpoke Well, the next at the Radio Tower, etc.
I third this.
All of your party pokes minus pikachu are stolen are hidden with rocket executives/within rocket HQs and the PCs system is hacked and taken down. You have to journey through Johto with only Pikachu to get them again with a side Suicune plot.