There's a brief skit where a guy points out a bit of neck fat on ???. ??? turns around and it turns out she's "Oprah". "Oprah" starts glaring and clenches her fist. The guy's head explodes and she says "I made his head go boom!". The funniest part is her facial expression during that line. I'm pretty sure it was making fun of how she pretty much controls the lives of a good portion of the country. I remember I used to have a classmate growing up who was one of her loyal followers, which just made it funnier.
Yeah, outside of a few skits that make the rounds on social media, pretty much the only time I watch Saturday Night Live nowadays is when Charles Barkley is hosting.