Given the advancement of technology is essentially exponential (seriously, look at what we had 20 years ago!), I predict that Pokemon games will probably tied to a global network that can be connected to on your wrist and you'll have a headset where you can walk around the real world and see Pokemon that can see and interact with you (i.e. they're ghosts in the machine). There probably won't be actual Pokemon because of the potential dangers, but I'd still like to have actual Pokemon.
4e is not D&D, but WoW making a Disguise check. Pokemon Black Friend Code: 0605-2800-9952; Trainer Name: Solace; First Pokemon (roleplaying): Snivy (Monty)