The more you play, the better you'll get with it. As a right handed person, my opinion on this matter might not be that great, but my right hand is pretty messed up, so when it comes to other things I'd normally have to do with my right hand, I end up having to use my left hand. You can train yourself to be ambidextrous, it'll take a while for your right to be just as good as your left, but you can surely bring their abilities closer together.
I think it'd be a good idea if they allowed people to special order left handed handhelds/controllers, without bumping up the price, but I don't know if we'd see this day anytime soon.
3DS FC: 2852-8061-6986 Currently Playing: Pokemon X/Y - Let me know if you add me, so I can add you!