League of Legends and Pokémon. Actually, this would work great. You are the pokemon traniner and you control your own pokemon in a real time birds-eye view MOBA environment to the destroy the enemy teams Pokemon Center. Items can be bought at Pokemon Marts and theres' enough of a variety of pokemon to cover various roles such as tank, ranged dps, support etc.
You know, this sounds awesome actually. Pwetty please GameFreak? I think there'd be enough of an audience for it as many people who started as a kid or their early teens with pokemon Red/ Blue/ Green are now grown ups who still play the series to this day.