Are you asking about on an actual Gameboy/Gameboy Color/Gameboy Advance? Are you asking about RNG manipulation in a tool-assisted run? You know, you could be a little more specific than just posting 'topic' as your message. Sheesh.
If you're talking about the way it can be manipulated on a real console like in later generations, no it can't be. It relies on the passing of time very precisely. So the only way to control it is by timing your button presses with a level of precision that can't be achieved on a real console. On an emulator, you can slow down the system to make it possible to time.