Nnot really. I mean, all the info you need you get from books and papers you need to fetch for Edwinna, then you need either Yagrum (who you'll have to meet during the corprus quest) or Baladas (who you can visit anytime you want) to put it together. I usually wrap up the Mage's guild before the MQ. --- For who could ever...?
Wait, wait, wait. You can actually solve the Disappearance of the Dwarves? I always assume it was just there to make Trebonius look like a dick. Which I guess, maybe it still is. --- ...and that's how I came to be known as the Flourescent Haberdasher.
To be fair your reward is spoiling a LOT of the main quest's plot.
Since you're most likely to solve it at a point where you know the main quest plot, I hardly think that's a problem. --- Why shouldn't truth be stranger than fiction? Fiction, after all, has to make sense.--Mark Twain