Dude, Malkavians are one of the best clans, IMHO. I love playing Malkavians in this game. The game is slightly (and I mean SLIGHTLY) different for Malks than it is for other clans. If you play a Malk, when you first get to your Haven, turn on the tv and listen the the newscaster for a while. He'll say some interesting stuff at one point. Dementation is a fun Discipline, especially when you can use it during conversation.
And what's better than arguing with a stop sign? I nearly peed myself the first time it happened.
Tremere are very flexible and adaptable to whatever your style of play is. Plus, Thaumaturgy rocks!
I'd save the Malk playthrough for a second (or third!) playthrough, as their dialogue is so different and sometimes hard to figure out. If you've gone through the game before with normal dialogue, you'll have a better idea of what's going on when you play again as a Malk. They're great fun, though: you simply must play as one at least once!
i don't know. i prefer to save malk playthrough for the last, not as early as second or third. because after playing as a malkavian, the other clans' dialogues will seem so.. vanilla. that's make some people lose interest (including me!)
My first toon was a Malkavian and I ended up playing a Ventrue instead because it was my first playthrough and Malkavian dialogue didn't make much sense to me so I didn't really know what was going on. I'd play something else first so you get the jist of what's going on then play a Malkavian afterwards. Don't get me wrong, Malkavians are hilarious, they just obscure the game on a first playthrough. At least they did for me. :P