Have you listened to any of the game's sounds using Windows Media Player? That would be a likely cause for the crash. WMP is evil in that regard.
Best course of action - backup your saves, reinstall the game and reapply the patch/mods you had. The exact same versions as before. Then continue your game. --- We do what we must / because we can. / For the good of all of us. / Except the ones who are dead.