In the Hooniversity, they witness a beanbean person transform into a Laser Snifit and then proceed to kill it. They do this to the others too. Does that make them murderers?
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I don't think it works that way if it's in self defense. For example, if my best friend turned into a Werewolf and came at me... well it's me or him, just saying.
Why are you reading this?
Aren't the blocks and such in SMB actually the residents of the Mushroom Kingdom Bowser caught and transformed with magic? If that was the case, then it's not like they haven't been doing this all their life.
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Murder implies pre-meditation (at least 1st degree).
I wouldn't even say it's manslaugther, more likely, it's self-defence.
Plus, one can argue that the laser-snifit transformed professor was actually knocked-out, and for gameplay reasons, he just disappeared so you could continue on.
"Those who would sacrifice liberty for security, deserve neither."