There was a great game by Nintendo for the GBA called Sound Voyager. You could play the whole game with just your ears, in fact you were encouraged to because as the levels progressed, it gets dark, until you can no longer see, and it was fun. Unfortunately it was just released in Japan. However it is import friendly, the very few words are in english. Otherwise, check it out with an emu.
Civ V brave new world then play as Venice. Enrico Dandolo was blind and Venezia has a unique UA (Serenissima: you can't make settlers and settlers gained would become merchants of Venice instead.) Also the UU would enable you to buy a city-state to expand.
AC new leaf FC: 1547-5212-4948. Name: Miiguel Town name: Tower