How large is your hand? i have large hands, and there is not a single mouse in existence that is comfortable for me. Controllers are the same, they are all too small.
I basically use a gel pad for my wrist/lower palm, with my fingertips on the mouse. I would love to find a really large mouse that let me actually put my palm on it, but they don't exist. I recommend looking for a comfortable palm/hand gel rest (mine is from razer).
It is a capital mistake to theorize before one has data. ...one begins to twist facts to suit theories.... Sir Arthur Conan Doyle