This is a split board - You can return to the Split List for other boards.
Drox Operative is a great example of what you're looking for. It takes the ARPG formula, drops it in space, and gives it a bunch of AI races playing a 4X game in the background.
Krater is kinda that, I suppose, though it's more post-apocalyptic, and you control a 3 man squad instead of a single person.edit: Oh, hey, sci-fi action RPG is today's WTF Is. http://www.youtube.com/watch?v=objnOfNf5yI
You are not allowed to request a sticky.